Regulation of G1/s Cell Cycle Progression by Transforming Growth Factor-ß
نویسندگان
چکیده
1 Downregulation of Cdk6 kinase activity is crucial for TGF-ß induced growth inhibition (I) ………………………………………………………………………………….38 1.1 TGF-ß growth inhibition is attenuated by overexpression of wild type Cdk6 …………38 1.2 Cyclin D-related kinase activity is maintained in wild type Cdk6-overexpressing cells treated with TGF-ß …..……………………………………………………………….39 1.3 Cdk2-associated kinase activity is partially maintained in TGF-ß-treated wild type Cdk6-overexpressing cells ..……………………………………………………40 1.4 Cdk6 and Cdk4 but not Cdk2 drive re-entry of TGF-ß-arrested Mv1Lu cells into the S-phase …………………………………………………………………40 2 TGF-ß signaling is regulated by proteasomal inhibitor in a gene-specific manner (II) ….…..41 2.1 Phospho-Smad2 protein level is increased upon inhibition of proteasome Activity ….…………………………………………………………………………….
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